Working with Industry


Prof Harry Anderson and IBM
Synthesis of Cyclo[18]carbon via Debromination of C18Br6
J. Am. Chem. Soc. 29 Jul 2020, 142, 30, 12921–12924
Prof Dermot O'Hare and SCG
Metallocene Polyethylene Wax Synthesis
Macromolecules, 28 Jul 2020, 53, 14, 5847–5856
Prof Charlotte Williams and Johnson Matthey
Cu/M:ZnO (M = Mg, Al, Cu) colloidal nanocatalysts for the solution hydrogenation of carbon dioxide to methanol
Journal of Materials Chemistry A, 2020, 8, 11282-11291
Prof Paul Beer and Johnson Matthey
N‐Functionalised Imidazoles as Stabilisers for Metal Nanoparticles in Catalysis and Anion Binding
Chemistry Open, 8 June 2020, vol. 9, issue 6, 683-690
Profs Fernanda Duarte and Ed Anderson, and Janssen
Rationalizing the diverse reactivity of [1.1.1]propellane through σ–π-delocalization
Chemical Science, 2020,11, 4895-4903
Prof Veronique Gouverneur, Pfizer, UCB and Janssen
Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
J. Am. Chem. Soc. 20 May 2020, 142, 20, 9181–9187
Prof Ed Anderson, Pfizer and Syngenta
Synthesis of All‐Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron‐Catalyzed Kumada Cross‐Coupling
Angewandte Chemie, 13 Jul 2020, vol. 59, issue 29, 11866-11870
Profs Veronique Gouverneur and Michael Willis, and Janssen
Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation
Angewandte Chemie, 6 Jul 2020, vol. 59, issue 28, 11620-11626
Prof Jonathan Burton and Pfizer
Organophotochemical SNAr Reactions of Mildly Electron‐Poor Fluoroarenes
European Journal of Organic Chemistry, 14 May 2020, issue 18, 2766-2770
Prof Ed Anderson and UCB
A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids
Organic Letters, 2020, 22, 4, 1510–1515
Profs Veronique Gouverneur and Michael Willis, and Janssen
Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
J. Am. Chem. Soc. 2020, 142, 2, 720–725
Prof Angela Russell and Summit Therapeutics
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model
Tetrahedron, Volume 76, Issue 2, 10 January 2020

Prof Angela Russell and Summit Therapeutics, SHB Enterprises and Evotec
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid
Angewandte Chemie International Edition, Volume 59, Issue 6, pages 2420-2428

Prof Angela Russell and Summit Therapeutics
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase
Bio-organic Chemistry, Volume 94, Article 103395, January 2020

Prof Darren Dixon and Bayer
Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to alpha-Fluorinated Ketones
Angewandte Chemie International Edition, February 2020



Prof Tim Claridge and Bruker
Triplet NOAH supersequences optimised for small molecule structure characterisation
MRC, 2019, Vol 57: Issue 11

Prof Darren Dixon and Bayer
One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines
Angewandte Chemie, 2019, Vol 58: Issue 8

Prof Timothy Donohoe and Eli Lilly
Transition-Metal-Free Reductive Hydroxymethylation of Isoquinolines
Angewandte Chemie, 2019, Vol 58: Issue 44

Prof Michael Willis and Pfizer
Cyclic Alkenylsulfonyl Fluorides: Palladium-Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents
Angewandte Chemie, 2019, Vol 58; Issue 52

Prof Timothy Donohoe and GSK
Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Chemical Science, 2019 Issue 25

Prof Veronique Gouverneur and Janssen
Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
Angewandte Chemie, 2019, DOI 10.1002/anie.201903801

Prof Ed Anderson and Janssen
A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides
Organic Letters, 2019, 21, 8, 2918-2922

Prof Ed Anderson and Pfizer
Synthesis of Enantioenriched α-Chiral Bicyclo[1.1.1]pentanes
Organic letters, 2019, 21 (7), pp 2408–2411

Prof Justin Benesch and Waters Corp
Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry
Journal of the American Society for Mass Spectrometry, 2019, 30: 45

Prof Véronique Gouverneur, Pfizer and UCB
Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride
Chemical Science, 2019, DOI 10.1039/C8SC05096A

Prof Stephen Fletcher and Vertex Pharmaceuticals
Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Nature Communications, 2019, 10, Article number: 21



Prof Tim Donohoe and Eli Lilly
The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation
Nature Chemistry, 2018. DOI 10.1038/s41557-018-0178-5

Prof Akane Kawamura and Promega Corporation
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Angewandte Chemie, 2018. 10.1002/anie.201810179

Prof Michael Willis and Pfizer
Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions
Journal of the American Chemical Society, 2018, 140 (46), pp 15916–15923

Prof Darren Dixon and Bayer
One‐Pot Catalytic Enantioselective Synthesis of 2‐Pyrazolines
Angewandte Chemie, 2018. DOI 10.1002/anie.201811471

Prof Carol Robinson, Prof Luet Wong and OMass
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
Science 2018, DOI 10.1126/science.aat8923

Prof Michael Willis and Evotec
Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Organic & Biomolecular Chemistry 2018, 16, 7797-7800

Prof Darren Dixon and Astex
Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines
Organic Letters 2018, DOI 10.1021/acs.orglett.8b02923

Prof Tom Brown and AstraZeneca
Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue
Scientific reports 2018, DOI 10.1038/s41598-018-31897-2

Prof Michael Willis and GlaxoSmithKline
Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol
Organic Letters 2018, 20 (17), pp 5493–5496.

Prof Angela Russell and AstraZeneca
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors
ACS Chemical Biology 2018, DOI 10.1021/acschembio.8b00665

Prof Carol Robinson and OMass
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Nature 2018, 559, 423–427.

Prof Harry Anderson and IBM
Polyyne formation via skeletal rearrangement induced by atomic manipulation
Nature Chemistry 2018, 10, 853–858.

Prof Tim Claridge and Bruker UK Ltd
Molecular structure from a single NMR supersequence
Chemical communications 2018, 54, 7139-7142.

Profs Hagan Bayley, Justin Benesch and Carol Robinson with OMass
Lipid binding attenuates channel closure of the outer membrane protein OmpF
PNAS 2018, DOI 10.1073/pnas.1721152115

Prof Justin Benesch and Prof Carol Robinson and Waters Corporation
Identifying key membrane protein lipid interactions using mass spectrometry
Nature Protocols 2018, 13, 1106–1120.

Prof Stuart Conway and GlaxoSmithKline
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Bioorganic & medicinal chemistry 2018, 26 (11), 2937-2957.

Prof Edward Anderson and Pfizer
Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes
Chemical Science 2018, DOI 10.1039/C8SC01355A

Prof Tom Brown with Baseclick and Metabion
Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
Chemical Communications 2018, DOI 10.1039/C8CC00738A

Prof Chris Schofield, Prof Shabaz Mohammed and Dr Emily Flashman with Novartis and AbbVie
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase
Extremophiles 2018, 22: 553. DOI 10.1007/s00792-018-1016-9

Prof Tom Brown and AstraZeneca
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
Chemical Science 2018, 9, 3494-3502, DOI 10.1039/C7SC05448C

Prof Veronique Gouverneur and Lilly
Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Science 2018, 360, 638-642.

Profs Andrew Weller and Mike Willis with AstraZeneca
Rh(DPEPhos)-Catalyzed Alkyne Hydroxylation Using -Carbonyl-Substituted Aldehydes: Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale
J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.8b04086

Prof Fraser Armstrong and SCG
A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring
Chem. Comm. 2018, 54, 972-975.

Prof Justin Benesch and Waters Corporation
Mass spectrometry beyond the native state
Current Opinion in Chemical Biology 2018, 42, 130-137.

Profs Darren Dixon, Christopher Schofield, Martin Smith, Mike Willis and UCB
Direct sulfonylation of anilines mediated by visible light 
Chem. Sci. 2018, 9, 629-633.

Prof Dermot O'Hare and SCG
Slurry-Phase Ethylene Polymerisation Using Pentafluorophenyl- and Pentafluorophenoxy- Modified Solid Polymethulaluminoxanes
Organometallics 2018, 37, 156-164.

Prof Chris Schofield and GSK
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces
ChemMedChem 2018, 13, 1051-1057.

Profs Steve Fletcher and Rob Paton with Vertex
Formation of quaternary centres by copper catalysed asymmetric conjugate addition to beta-substituted cyclopentneones with the aid of a quantitative structure-selectivity relationship
Chem. Sci. 2018, 9, 2628-2632.

Prof Darren Dixon and UCB
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macro domain 2
Bioorg & Med. Chem. 2018, dos 10.1016/j.bmc.2018.03.020

Prof Mike Willis and GSK
Oxidative Beta-Sulfonylation of Cyclic Amines
Chem. Sci. 2018, 9, 2295-2300.



Prof Dermot O'Hare and SCG
Zirconium arena triple-decker sandwich complexes: synthesis, electronic structure and bonding
Chem. Comm. 2017, 53, 12048-12051.

Profs Darren Dixon, Rob Paton, Christopher Schofield, Martin Smith, Mike Willis and UCB
A C-H Cyanation of 6-Ring N-Containing Heteroaromatics 
Chem. Eur. J. 2017, 23, 14733-14737.

Prof Andrew Baldwin and ZoBio
Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory
J. Am. Chem. Soc. 2017, 139, 9523-9533.

Prof Mike Willis and UCB
One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
Angew. Chem. Int. Ed. 2017, 56, 14937-14941.

Prof Carol Robinson and OMass
Native Desorption Electrospray Ionisation Liberates Soluble and Membrane Protein Complexes from Surfaces
Angew. Chem. Int. Ed.  2017, 56, 14463-14468.

Prof Veronique Gouverneur and UCB
Derisking the Cu-Mediated F-18-Fluorination of Heterocyclic Positron Emission Tomography
J. Am. Chem. Soc. 2017, 139 (24), 8267-8276.

Prof Tim Claridge and Bruker
NOAH - NMR Supersequences for Small Molecule Analysis and Structure Elucidation
Angew. Chem. Int. Ed.  2017, 129, 11941-11945.

Prof Veronique Gouverneur and UCB
Derisking the Cu-Mediated F-18-Fluorination of Heterocyclic Positron Emission Tomography
J. Am. Chem. Soc. 2017, 139 (24), 8267-8276.

Prof Edman Tsang and SINOPEC
Decarboxylation of Lactones over Zn/ZSM-5: Elucidations of the Structure of the Active Site and Molecular Interactions
Angew. Chem. Int. Ed. 2017, 129, 10851-10856.

Prof Tom Brown and AstraZeneca
Towards Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
J. Am. Chem. Soc. 2017, 139 (27), 9271-9280.

Prof Philip Mountford and SCG
Reactions of Titanium Imides and Hydrazides with Boranes
Organometallics 2017, 36, 3329-3342.

Prof Veronique Gouverneur and UCB
Bridging the gaps in 18F PET tracer development
Nat. Chem. 2017, 9 (1), 1-3.

Profs Luet Wong and Jeremy Robertson and Syngenta
Hydroxylation of anilines by engineered cytochrome P450(BM3)
Org. Biomol. Chem. 2017, 15, 8780-8787.

Prof Tim Donohoe and GSK
Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of beta-Branched Carbonyl Compounds
J. Am. Chem. Soc. 2017, 139 (7), 2577-2580.

Prof Mike Willis and Pfizer
Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalysed cross-coupling reactions with aryl halides
Chem. Sci. 2017, 8, 4437-4442.

Prof Philip Mountford and Arlanxeo
Monometallic and Bimetallic Titanium K1-Amidinate Complexes as Olefin Polymerisation Catalysts
Organometallics, 2017, 36 (11), 2167-2181.

Prof Carol Robinson and Spiber Technologies
Efficient protein production inspired by how spiders make silk
Nat. Comm. 2017, 8, 15504.

Profs Dermot O'Hare and Edman Tsang and SCG
Hydrodeoxygenation of water-insoluble bio-oil to alkanes using highly dispersed Pd-Mo catalyst
Nature Comm. 2017, 8, 1591.

Prof Veronique Gouverneur and Eli Lilly
The dual role of thiourea in the thiotrifluoromethylation of alkenes
Chem. Sci. 2017, 8, 1195-1199.

Prof Ed Anderson and Pfizer
Mechanistic Study of Arylsilane Oxidation through 19-F NMR Spectroscopy
J. Am. Chem. Soc. 2017, 139 (17), 6138-6145.

Prof Roel Dullens, Prof Dirk Aarts and Unilever
The effect of colloidal aggregates on fat crystal networks
Food Funct. 2017, 8 (1), 352-359.

Prof Tim Donohoe and AstraZeneca
Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of beta-Carbolines
J. Org. Chem. 2017, 82 (8), 4435-4443

Prof Philip Mountford and SCG
New Titanium Borylimido Compounds: Synthesis, Structure and Bonding
Inorg. Chem. 2017, 56, 10794-10814.

Prof Veronique Gouverneur and Advion Biosystems
Synthesis and Reactivity of F-18-Labeled alpha,alpha-Difluoro-alpha(aryloxy(acetic Acids
Org. Lett. 2017, 19 (3), 568-571.

Prof Darren Dixon and UCB
Discovery of a PCAF Bromodomain Chemical Probe
Angew. Chem. Int. Ed. 2017, 56, 827.

Prof Mike Willis and Pfizer
One-pot palladium-catalysed synthesis of sulfonyl fluorides from aryl bromides
Chem. Sci. 2017, 8, 1233-1237.



Prof Dermot O'Hare and SCG
Synthesis and Characterisation of Solid Polymethylaluminoxane: A Bifunctional Activator and Support for Slurry-Phase Ethylene Polymerisation
Chem. Mater. 2016, 28 (20), 7444-7450.

Prof Martin Smith and GSK
Catalytic Enantioselective Synthesis of C1- and C2- Symmetric Spirobiindanones through Counterion-Directed Enolate C-Acylation
Angew. Chem. Int. Ed.  2016, 55 (42), 13180-13183.

Prof Luet Wong, Prof Jeremy Robertson and Syngenta
Synthesis of Imidazolidin-4-ones via a Cytochrome P450-Catalyzed Intramolecular C-H Amination
ACS Catal. 2016, 6 (10), 6833-6837.

Prof Roel Dullens, Prof Dirk Aarts and Unilever
Segregated Ice Growth in a Suspension of Colloidal Particles
J. Phys. Chem. B 2016, 120 (16), 3941-3949.

Prof Carol Robinson and Oxford Nanopore
Crystal structure of an invertebrate cytolysis pore reveals unique properties and mechanism of assembly
Nat. Comms. 2016, 7, 11598

Prof Darren Dixon and UCB and Promega
Discovery of a PCAF Bromodomain Chemical Probe
Angew. Chem. Int. Ed.  2016, 56 (3), 827-831.

Dr Akane Kawamura, Prof Chris Schofield and SGC, Diamond Light Source, GSK
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
J. Med. Chem. 2016, 59 (4), 1388-1409 Article No. SI.

Prof Carol Robinson and Novo Nordisk
Structural and Functional Characterisation of the Bacterial Type III Secretion Export Apparatus
PLOS Pathogens 2016, 12 (12)

Prof Richard Compton and Johnson Matthey
Effect of cation structure on the oxygen solubility and diffusivity in a range of bis{(trifluoromethyl)sulfonyl}amide anion based ionic liquids for lithium-air battery electrodes
Phys. Chem. Them. Phys. 2016, 18, 11251-11262

Prof Mike Willis and Syngenta
Palladium(II)-Catalyzed Synthesis of Sulfinates from Boronic Acids and DABSO: A Redox-Neutral, Phosphine-Free Transformation
Angew. Chem. Int. Ed.  2016, 55 (2), 747-750.

Prof Ben Davis and GlycoVaxyn AG
An antibacterial vaccination strategy based on a glycoconjugate containing the core lipopolysaccharide tetrasaccharide Hep(2)Kdo(2)
Nat. Chem. 2016, 8 (3), 242-249

Prof Edman Tsang and Samsung
Gain Spectroscopy of Solution-Based Semiconductor Nanocrystals in Tunable Optical Microcavities
Adv. Opt. Mater. 2016, 4 (2), 285-290

Prof Tim Donohoe and GSK
Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines
Org. Biomol. Chem. 2016, 14 (3), 1065-1090

Prof Fraser Armstrong and SCG
Catalysis of solar hydrogen production by iron atoms on the surface of Fe-doped silicon carbide
Catal. Sci.Technol. 2016, 6, 7038.

Prof Carol Robinson and GSK
Elucidation of Drug Metabolite Structural Isomers Using Molecular Modeling Coupled with Ion Mobility Mass Spectrometry
Anal. Chem. 2016, 88 (4), 2273-2280

Prof Mark Moloney and Ketonex
Spherical, particulate poly(ether ketone ketone) by a Friedel Crafts dispersion polymerisation
RSC Adv. 2016, 6 (17), 13809-13819

Prof Darren Dixon and Evotec
Chemical probes and inhibitors of bromodomains outside the BET family
Med. Chem. Commun.  2016, 7, 2246-2264.

Prof Ben Davis and Badrilla Ltd
Ready display of antigenic peptides in a protein 'mimogen'
Chem. Comm. 2016, 52 (14), 3014-3017

Prof Carol Robinson and Sony Corp
Programmable polyproteams built using twin peptide superglues
Proc. Natl. Acad. Sci. 2016, 113 (5), 1202-1207

Prof Veronique Gouverneur, Advion Biosystems and GSK
Silver-Mediated F-18-Labeling of Aryl-CF3 and Aryl-CHF2 with F-18-Fluoride
Synlett 2016, 27 (1), 25-28

Prof Carol Robinson and Thermo Fisher
High-resolution mass spectrometry of small molecules bound to membrane proteins
Nat. Methods 2016, 13, 333-336

Prof Edman Tsang, Diamond Light Source and Siemens
Probing atomic positions of adsorbed ammonia molecules in zeolite
Chem. Comm. 2016, 52 (16), 3422-3425 

Prof Ben Davis and GSK
Evaluation of the non-toxic mutant of the diphtheria toxin K51E/E148K as carrier protein for meningococcal vaccines
Vaccine 2016, 34 (11), 1405-1411



Prof Tom Brown and ATDBio
Reversible Energy-Transfer Switching on a DNA Scaffold
J. Am. Chem. Soc. 2015, 137 (7), 2444-2447

Prof Richard Compton and Micrux
Validating the geometry of interdigitated band electrodes: A variable scan rate study.
J. Electroanal. Chem. 2015, 748, 82-90

Prof Shabaz Mohammed and Thermo Fisher Scientific
Rapid Analyses of Proteomes and Interactomes Using an Integrated Solid-Phase Extraction Liquid Chromatography-MS/MS System
J. Proteome Res. 2015, 14 (2), 977-985

Dr Nick Green and BIOVIA
Reanalysis of Rate Data for the Reaction CH3 + CH3 -> C2H6 Using Revised Cross Sections and a Linearized Second-Order Master Equation
J. Phys. Chem. A 2015, 119 (28), 7668-7682

Prof Veronique Gouverneur, Advion BioSyst Inc and GE Healthcare
Oxidative fluorination of N-arylsulfonamides
J. Fluorine Chem. 2015, 180, 33-39

Prof Veronique Gouverneur and Advion BioSyst Inc
Synthesis of F-18-arenes from spirocyclic iodonium(III) ylides via continuous-flow microfluidics
J. Fluorine Chem. 2015, 178, 249-253

Prof Ed Anderson, Syngenta and AstraZeneca
Ynamide Carbopalladation: A Flexible Route to Mono-, Bi- and Tricyclic Azacycles
Chem. Eur. J. 2015, 21 (36), 12627-12639

Dr Tiancun Xiao and Guangzhou Boxabio Technol Ltd
Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL
Int. J. Mol. Sci. 2015, 16 (8), 17245-17272

Prof Dermot O’Hare and SCG Chemicals Co
Tuneable ultra high specific surface area Mg/Al-CO3 layered double hydroxides
Dalton Trans. 2015, 44 (37), 16392-16398

Prof Darren Dixon and Promega Corp

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
Angew. Chem. Int. Ed. 2015, 54 (21), 6217-6221.

Prof Paul Beer and DSTL Porton Down
Contrasting anion recognition behaviour exhibited by halogen and hydrogen bonding rotaxane hosts
Org. Biomol. Chem. 2015, 13 (9), 2582-2587.

Prof Steve Davies and Syngenta
Pinacolatoboron fluoride (pinBF) is an efficient fluoride transfer agent for synthesis of benzylic fluorides
Tetrahedron Lett. 2015, 56, 3373-3377.

Prof Steve Davies and AstraZeneca
Asymmetric syntheses of polysubstituted homoprolines and homoprolinols
Tetrahedron 2015, 71, 9131-9142.

Prof Steve Davies and AstraZeneca
Concise total asymmetric syntheses of (–)-fagomine, two of its epimers, and two seven-membered ring congeners
Tetrahedron 2015, 71, 7170-7180.

Prof Michael Willis and Syngenta
Combining organometallic reagents, the sulfur dioxide surrogate DABSO, and amines:  A one-pot prepration of sulfonamides, amenable to array synthesis
Angew. Chem. Int. Ed. 2015, 54, 1168-1171.

Prof Peter Edwards and SINOPEC
Catalytic dehydrogenation of propane by carbon dioxide: a medium-temperature thermochemical process for carbon dioxide utilisation
Faraday Discuss. 2015, 183, 161-176.

Prof Tom Brown and LGC
Synthesis and use of universal sequence probes in fluorogenic multi-strand hybridisation complexes for economical nucleic acid testing
Mol. Cell. Probes 2015, 29 (4), 228-236.

Prof Tim Donohoe and GSK
Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones To Expand the Scope of Hydrogen Borrowing Catalysis
J. Am. Chem. Soc. 2015, 137 (50), 15664-15667.

Prof Angela Russell, Prof Steve Davies and Summit
Second-generation compound for the modulation of utrophin in the therapy of DMD​
Hum. Mol. Genet. 2015, doi: 10.1093/hmg/ddv154

Prof Mark Moloney and GSK
Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: access to annulated prolines
Org. Biomol. Chem. 2015, 13 (23), 6522-6550.

Prof David Hodgson and Novartis
Amine Protection/alpha-Activation with the tert-Butoxythiocarbonyl Group: Application to Azetidine Lithiation-Electrophilic Substitution
Organic Letters 2015, 17 (2), 330-333.

Dr Tiancun Xiao and Guangzhou Boxabio Technol Ltd
Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
Mar. Drugs 2015, 13 (5), 2732-2756.

Prof David Hodgson, Rob Paton, Tim Claridge and Novartis
α- and α-Lithiation–Electrophile Trapping of N-Thiopivaloyl and N-tert-Butoxythiocarbonyl α-Substituted Azetidines: Rationalization of the Regiodivergence Using NMR and Computation.
J. Org. Chem. 2015, 80 (20), 9838–9846.

Prof Edman Tsang and Johnson Matthey
Dual doping effects (site blockage and electronic promotion) imposed by adatoms on Pd nanocrystals for catalytic hydrogen production
Chem. Commun. 2015, 51 (1), 46-49.

Prof Roel Dullens, Prof Dirk Aarts and InProcess-LSP
Microscopic dynamics of synchronization in driven colloids
Nat. Commun. 2015, 6, Article No. 7187.

Prof George Fleet, BioApply and Phytoquest Ltd
Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors
Phytochem. 2015, 111, 124-131.

Prof George Fleet and Phytoquest Ltd
Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal alpha-Glucosidases: Binding Conformation and Interaction for ntSI
J. Org. Chem. 2015, 80 (9), 4501-4515.

Prof Veronique Gouverneur and Advion
F-18-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [F-18]Fluoride
Angew. Chem. Int. Ed. 2015, 54 (34), 9991-9995.

Prof Stephen Faulkner and Promega Corp
Development of an enzymatic pretargeting strategy for dual-modality imaging
Chem. Comm. 2015, 51 (19), 4055-4058.

Prof Jeremy Robertson and Buker Daltonik
Unique metabolites protect earthworms against plant polyphenols
Nat. Commun. 2015, 6, Article No. 7869.

Prof Carol Robinson, Prof Martin Smith and Peptide Prot Res Ltd, Cambridge MedChem Consulting
Bifunctional crosslinking ligands for transthyretin
Open Biol. 2015, 5 (9), Article No. 150105.

Prof Paul Beer and Johnson Matthey
A halogen- and hydrogen-bonding [2]catenane for anion recognition and sensing
RSC Adv. 2015, 5 (12), 9298-9306.

Prof Tom Brown, ATDBio and DSTL
Strain discrimination of Yersinia pestis using a SERS-based electrochemically driven melting curve analysis of variable number tandem repeat sequences
Chem. Sci. 2015, 6 (3), 1846-1852.

Prof Tom Brown, ATDBio and DSTL
Using Surface-Enhanced Raman Spectroscopy and Electrochemically Driven Melting to Discriminate Yersinia pestis from Y. pseudotuberculosis Based on Single Nucleotide Polymorphisms within Unpurified Polymerase Chain Reaction Amplicons
Anal. Chem. 2015, 87 (3), 1605-1612.

Prof Peter Edwards and ISIS Spallat Neutron & Muon Source
Questioning Antiferromagnetic Ordering in the Expanded Metal, Li(NH3)(4): A Lack of Evidence from mu SR
J. Phys. Chem. Lett. 2015, 6 (19), 3966-3970.

Prof Tim Donohoe and Novartis
Hydrogen-Borrowing and Interrupted-Hydrogen-Borrowing Reactions of Ketones and Methanol Catalyzed by Iridium
Angew. Chem. Int. Ed. 2015, 54 (5), 1642-1645.

Prof Justin Benesch, Prof Andrew Baldwin and Waters Corp
Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins
Int. J. Mass Spectrom. 2015, 377, 663-671 Article No. SI.

Prof Andrew Goodwin and DENSO CORP
Glass formation via structural fragmentation of a 2D coordination network
Chem. Commun. 2015, 51 (64), 12728-12731.



Prof Ed Anderson and Syngenta
Palladium-catalyzed cyclization of bromoenynamides to tricyclic azacycles: synthesis of trikentrin-like frameworks
Chem. Comm. 2014, 50 (40), 5187-5189.

Prof Hagan Bayley and Oxford Nanopore
Designing a Hydrophobic Barrier within Biomimetic Nanopores
Nano 2014, 8 (11), 11268-11279.

Prof Paul Beer and Johnson Matthey
Halotriazolium Axle Functionalised [2]Rotaxanes for Anion Recognition: Investigating the Effects of Halogen-Bond Donor and Preorganisation
Chemistry-a European Journal 2014, 20 (37), 11740-11749 .

Prof Gus Hancock, Prof Grant Ritchie, Oxford Children’s Hospital and Oxford Medical Diagnostics
Comparison of breath gases, including acetone, with blood glucose and blood ketones in children and adolescents with type 1 diabetes.
J. Breath Res. 2014, 8, 046010

Prof Michael Willis and AstraZeneca
Palladium-Catalyzed Synthesis of Ammonium Sulfinates from Aryl Halides and a Sulfur Dioxide Surrogate: A Gas- and Reductant-Free Process
Angew. Chem. Int. Ed. 2014, 53, 10204 –10208.

Prof Mark Brouard, Prof Claire Vallance and Scientific Analysis Instruments (SAI Ltd)
Modifications to a commercially available linear mass spectrometer for mass-resolved microscopy with the pixel imaging mass spectrometry (PImMS) camera
Rapid Commun. Mass Spectrom. 2014, 28, 1649

Prof Michael Willis and Syngenta
DABSO-Based, Three-Component, One-Pot Sulfone Synthesis

Org. Lett. 2014, 16 (1), 150-153.

Prof Steve Davies and AstraZeneca
Asymmetric syntheses of (–)-3-epi-fagomine, (2R,3S,4R)-dihydroxypipecolic acid and several polyhydroxylated homopipecolic acids
J. Org. Chem. 2014, 79, 10932.

Prof Jonathan Burton and AstraZeneca
Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks
Org. Lett. 2014, 16 (16), 4094-4097.

Prof Jonathan Burton and GSK
Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (-)-Salinosporamide A
Org. Lett. 2014, 16 (16), 4078-4081.

Prof Richard Compton and Schlumberger Cambridge Res Ltd
A flow system for hydrogen peroxide production at reticulated vitreous carbon via electroreduction of oxygen
Journal of Solid State Electrochemistry 2014, 18 (5), 1215-1221.

Prof Stuart Conway, Prof Robert Paton, SGC and Pfizer-Neusentis
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-pi Interaction
Angewandte Chemie-International Edition 2014, 53 (24), 6126-6130.

Prof Stuart Conway and Crysalin Ltd
Understanding the Structural Requirements for Activators of the Kef Bacterial Potassium Efflux System
Biochemistry 2014, 53 (12), 1982-1992.

Prof Bill David, Rutherford Appleton Lab and Toyota Motor Co
Understanding composition property relationships in Ti-Cr-V-Mo alloys for optimisation of hydrogen storage in pressurised tanks
Physical Chemistry Chemical Physics 2014, 16 (31), 16563-16572.

Prof Steve Davies and AstraZeneca
Asymmetric syntheses of (–)-3-epi-fagomine, (2R,3S,4R)-dihydroxypipecolic acid and several polyhydroxylated homopipecolic acids
Journal of Organic Chemistry 2014, 79 (22), 10932-10944.

Prof Ben Davis, Prof Shabaz Mohammed, Prof James McCullagh and Pfizer
Synthetic Phosphorylation of p38 alpha Recapitulates Protein Kinase Activity

Journal of the American Chemical Society 2014, 136 (5), 1698-1707.

Prof Ben Davis and GlycoVaxyn AG
Rationally Designed Short Polyisoprenol-Linked PglB Substrates for Engineered Polypeptide and Protein N-Glycosylation
Journal of the American Chemical Society 2014, 136 (2), 566-569.

Prof Ben Davis and UCB
Creation of a gated antibody as a conditionally functional synthetic protein
Nature Communications 2014, 5, Article No. 4388.

Prof Ben Davis and AstraZeneca
Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein
Chemical Science 2014, 5 (10), 3789-3794.

Prof Darren Dixon and AstraZeneca
One-Pot Asymmetric Nitro-Mannich/Hydroamination Cascades for the Synthesis of Pyrrolidine Derivatives: Combining Organocatalysis and Gold Catalysis
Catalysis 2014, 4 (2), 634-638.

Prof Tim Donohoe and AstraZeneca
New methods for the synthesis of naphthyl amines; application to the synthesis of dihydrosanguinarine, sanguinarine, oxysanguinarine and (+/-)- maclekarpines B and C
Chemical Communications 2014, 50 (77), 11314-11316.

Prof Tim Donohoe and AstraZeneca
De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
Organic Letters 2014, 16 (7), 1920-1923.

Prof Tim Donohoe and GSK
Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation
Angewandte Chemie-International Edition 2014, 53 (52), 14555-14558.

Prof George Fleet and Carbosynth Ltd
L-Fucose from Vitamin C with Only Acetonide Protection
Organic Letters 2014, 16 (21), 5663-5665.

Prof Andrew Goodwin, Rutherford Appleton Lab and ESS AB
Spin correlations in Ca3Co2O6: Polarized-neutron diffraction and Monte Carlo study
Physical Review B 2014, 90 (1), Article No. 014411.

Prof Veronique Gouverneur and UCB
A General Copper-Mediated Nucleophilic F-18 Fluorination of Arenes
Angewandte Chemie-International Edition 2014, 53 (30), 7751-7755.

Prof Veronique Gouverneur and Advion BioSyst
Diversity-Oriented Approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)(2)CH-, and CF3(SCF3)CH-Substituted Arenes from 1-(Diazo-2,2,2-trifluoroethyl)arenes
Organic Letters 2014, 16 (22), 6004-6007.

Prof Veronique Gouverneur and F Hoffman La Roche Ltd
Anti-CD20 therapy down-regulates lesion formation and microglial activation in pattern I and pattern II rat models of multiple sclerosis
Journal of Neuroimmunology 2014, 275 (1-2), 1-2.

Prof Veronique Gouverneur and GSK
A Comparison of the Behavior of Cu-64-Acetate and Cu-64-ATSM In Vitro and In Vivo
Journal of Nuclear Medicine 2014, 55 (1), 128-134.

Prof Malcolm Green and Sud Chemied India Pvt Ltd
Deep hydrotreating of different feedstocks over a highly active Al2O3-supported NiMoW sulfide catalyst
Applied Catalysis a-General 2014, 475, 270-281.

Prof Nicholas Green and Accelrys Inc
General master equation formulation of a reversible dissociation/association reaction
Chemical Physics Letters 2014, 605, 44-46.

Prof Gus Hancock, Prof Grant Ritchie and Oxford Medical Diagnostics Ltd
Laser-Based Method and Sample Handling Protocol for Measuring Breath Acetone
Analytical Chemistry 2014, 86 (12), 5838-5843.

Prof Shabaz Mohammed and Thermo Fisher Sci
Characterization and usage of the EASY-spray technology as part of an online 2D SCX-RP ultra-high pressure system
Analyst 2014, 139 (24), 6520-6528.

Prof Mark Moloney and Virtua Drug
A Detailed Study of Antibacterial 3-Acyltetramic Acids and 3-Acylpiperidine-2,4-diones
Chemmedchem 2014, 9 (8), 1826-1837.

Prof Jeremy Robertson and AstraZeneca
Substrate scope and stereocontrol in the Rh(II)-catalysed oxyamination of allylic carbamates
Tetrahedron 2014, 70 (40), 7388-7394 Article No. SI.

Prof Jeremy Robertson and AstraZeneca
Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans
Chemical Communications 2014, 50 (77), 11393-11396.

Prof Jeremy Robertson and Syngenta
Synthesis of Pandamarilactone-1
Organic Letters 2014, 16 (3), 884-887.

Prof Edman Tsang, Diamond Light Source and Johnson Matthey
Interstitial modification of palladium nanoparticles with boron atoms as a green catalyst for selective hydrogenation
Nature Communications 2014, 5, Article No. 5787.

Prof Edman Tsang and SINOPEC
Tuning enantioselectivity in asymmetric hydrogenation of acetophenone and its derivatives via confinement effect over free-standing mesoporous palladium network catalysts
Journal of Catalysis 2014, 313, 113-126.

Prof Edman Tsang and Johnson Matthey
Atomic Imaging of Carbon-Supported Pt, Pt/Co, and Ir@Pt Nanocatalysts by Atom-Probe Tomography
Catalysis 2014, 4 (2), 695-702.

Prof Michael Willis and Pfizer-Neusentis
One-pot three-component sulfone synthesis exploiting palladium-catalysed aryl halide aminosulfonylation
Chemical Science 2014, 5 (1), 222-228.

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