Prof Carol Robinson, Prof Luet Wong and OMass An electron transfer path connects subunits of a mycobacterial respiratory supercomplex Science 2018, DOI 10.1126/science.aat8923 Prof Michael Willis and Evotec Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes Organic & Biomolecular Chemistry 2018, 16, 7797-7800 Prof Darren Dixon and Astex Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines Organic Letters 2018, DOI 10.1021/acs.orglett.8b02923 Prof Tom Brown and AstraZeneca Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue Scientific reports 2018, DOI 10.1038/s41598-018-31897-2 Prof Michael Willis and GlaxoSmithKline Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol Organic Letters 2018, 20 (17), pp 5493–5496. Prof Angela Russell and AstraZeneca Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors ACS Chemical Biology 2018, DOI 10.1021/acschembio.8b00665 Prof Carol Robinson and OMass PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling Nature 2018, 559, 423–427. Prof Harry Anderson and IBM Polyyne formation via skeletal rearrangement induced by atomic manipulation Nature Chemistry 2018, 10, 853–858. Prof Tim Claridge and Bruker UK Ltd Molecular structure from a single NMR supersequence Chemical communications 2018, 54, 7139-7142. Profs Hagan Bayley, Justin Benesch and Carol Robinson with OMass Lipid binding attenuates channel closure of the outer membrane protein OmpF PNAS 2018, DOI 10.1073/pnas.1721152115 Prof Justin Benesch and Prof Carol Robinson and Waters Corporation Identifying key membrane protein lipid interactions using mass spectrometry Nature Protocols 2018, 13, 1106–1120. Prof Stuart Conway and GlaxoSmithKline BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability Bioorganic & medicinal chemistry 2018, 26 (11), 2937-2957. Prof Edward Anderson and Pfizer Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes Chemical Science 2018, DOI 10.1039/C8SC01355A Prof Tom Brown with Baseclick and Metabion Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures Chemical Communications 2018, DOI 10.1039/C8CC00738A Prof Chris Schofield, Prof Shabaz Mohammed and Dr Emily Flashman with Novartis and AbbVie YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase Extremophiles 2018, 22: 553. DOI 10.1007/s00792-018-1016-9 Prof Tom Brown and AstraZeneca Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue Chemical Science 2018, 9, 3494-3502, DOI 10.1039/C7SC05448C Prof Veronique Gouverneur and Lilly Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis Science 2018, 360, 638-642. Profs Andrew Weller and Mike Willis with AstraZeneca Rh(DPEPhos)-Catalyzed Alkyne Hydroxylation Using -Carbonyl-Substituted Aldehydes: Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.8b04086 Prof Fraser Armstrong and SCG A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring Chem. Comm. 2018, 54, 972-975. Prof Justin Benesch and Waters Corporation Mass spectrometry beyond the native state Current Opinion in Chemical Biology 2018, 42, 130-137. Profs Darren Dixon, Christopher Schofield, Martin Smith, Mike Willis and UCB Direct sulfonylation of anilines mediated by visible light Chem. Sci. 2018, 9, 629-633. Prof Dermot O'Hare and SCG Slurry-Phase Ethylene Polymerisation Using Pentafluorophenyl- and Pentafluorophenoxy- Modified Solid Polymethulaluminoxanes Organometallics 2018, 37, 156-164. Prof Chris Schofield and GSK Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces ChemMedChem 2018, 13, 1051-1057. Profs Steve Fletcher and Rob Paton with Vertex Formation of quaternary centres by copper catalysed asymmetric conjugate addition to beta-substituted cyclopentneones with the aid of a quantitative structure-selectivity relationship Chem. Sci. 2018, 9, 2628-2632. Prof Darren Dixon and UCB Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macro domain 2 Bioorg & Med. Chem. 2018, dos 10.1016/j.bmc.2018.03.020 Prof Mike Willis and GSK Oxidative Beta-Sulfonylation of Cyclic Amines Chem. Sci. 2018, 9, 2295-2300.