Working with Industry

Department of Chemistry University of Oxford

Prof Tim Claridge and Bruker UK Ltd
Molecular structure from a single NMR supersequence
Chemical communications 2018, 54, 7139-7142

Profs Hagan Bayley, Justin Benesch and Carol Robinson with OMass
Lipid binding attenuates channel closure of the outer membrane protein OmpF
PNAS 2018, DOI 10.1073/pnas.1721152115

Prof Justin Benesch and Prof Carol Robinson and Waters Corporation
Identifying key membrane protein lipid interactions using mass spectrometry
Nature Protocols 2018, 13, 1106–1120

Prof Stuart Conway and GlaxoSmithKline
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Bioorganic & medicinal chemistry 2018, 26 (11), 2937-2957

Prof Edward Anderson and Pfizer
Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes
Chemical Science 2018, DOI 10.1039/C8SC01355A

Prof Tom Brown with Baseclick and Metabion
Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
Chemical Communications 2018, DOI 10.1039/C8CC00738A

Prof Chris Schofield, Prof Shabaz Mohammed and Dr Emily Flashman with Novartis and AbbVie
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase
Extremophiles 2018, 22: 553. DOI 10.1007/s00792-018-1016-9

Prof Tom Brown and AstraZeneca
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
Chemical Science 2018, 9, 3494-3502, DOI 10.1039/C7SC05448C

Prof Veronique Gouverneur and Lilly
Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Science 2018, 360, 638-642.

Profs Andrew Weller and Mike Willis with AstraZeneca
Rh(DPEPhos)-Catalyzed Alkyne Hydroxylation Using -Carbonyl-Substituted Aldehydes: Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale
J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.8b04086

Prof Fraser Armstrong and SCG
A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring
Chem. Comm. 2018, 54, 972-975.

Prof Justin Benesch and Waters Corporation
Mass spectrometry beyond the native state
Current Opinion in Chemical Biology 2018, 42, 130-137.

Profs Darren Dixon, Christopher Schofield, Martin Smith, Mike Willis and UCB
Direct sulfonylation of anilines mediated by visible light 
Chem. Sci. 2018, 9, 629-633.

Prof Dermot O'Hare and SCG
Slurry-Phase Ethylene Polymerisation Using Pentafluorophenyl- and Pentafluorophenoxy- Modified Solid Polymethulaluminoxanes
Organometallics 2018, 37, 156-164.

Prof Chris Schofield and GSK
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces
ChemMedChem 2018, 13, 1051-1057.

Profs Steve Fletcher and Rob Paton with Vertex
Formation of quaternary centres by copper catalysed asymmetric conjugate addition to beta-substituted cyclopentneones with the aid of a quantitative structure-selectivity relationship
Chem. Sci. 2018, 9, 2628-2632.

Prof Darren Dixon and UCB
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macro domain 2
Bioorg & Med. Chem. 2018, dos 10.1016/j.bmc.2018.03.020

Prof Mike Willis and GSK
Oxidative Beta-Sulfonylation of Cyclic Amines
Chem. Sci. 2018, 9, 2295-2300.